This is the type of book that you read, and you actually learn from. The focus is on the societies in the Americas, in particular Meso-America, prior to the discovery or arrival of Europeans. There is quite a bit about the societies but also about why diseases affected Native Americans far differently than Africans.
Mann debunks or seriously challenges long held beliefs that make their way into textbooks, even today when Columbus has lost his historical status in much of the United States.
I found the sections about North American Natives and the crafting of the land to be the most interesting.